Opinion: The Code Breaker, CRISPR, and the UN Summit

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Note: This article appeared originally in Agri-Pulse https://www.agri-pulse.com/articles/15518-opinion-the-code-breaker-crispr-and-the-un-summit

“CRISPR’s gene-editing “molecular machine” harnesses the precision of enzymes and RNA to accurately find and edit existing genes to achieve advantageous biological outcomes.”

As preparations for the United Nations Food System Summit (FSS) get underway in the US and around the world, the respected author Walter Isaacson has released a new book entitled The Code Breaker. Isaacson, well known as a talented historian and biographer, has written eloquently of Albert Einstein, Benjamin Franklin, Steve Jobs and Leonardo da Vinci. The Code Breaker points us toward a new frontier, focusing on “gene editing and the future of the human race.” 

Jennifer Doudna
Jennifer Doudna 

The Code Breaker chronicles the professional path of Nobel Prize winners Jennifer Doudna and Emmanuelle Charpentier who developed CRISPR into a practical, versatile gene-editing technology. CRISPR’s gene-editing “molecular machine” harnesses the precision of enzymes and RNA to accurately find and edit existing genes to achieve advantageous biological outcomes. It is a far different approach than inserting transgenic traits from one organism into another. (CRISPR is shorthand for “clustered regularly interspaced short palindromic repeats.”)

On Friday, March 12, 2021, Washington Post reporter David Ignatius interviewed both Dr. Doudna and Walter Isaacson. Dr. Doudna made the point that CRISPR technology could be used to modify any type of cell, and it is “equally powerful as a tool for manipulating the genetic material in plants and so we have opportunities now in agriculture that were never available previously.”

CRISPR’s impact on food, agriculture and global hunger could be substantial. Dr. Nina V. Fedoroff, Emeritus Evan Pugh Professor at Penn State University and the Senior Science Advisor at OFW Law, noted “CRISPR technology holds great potential for agriculture, increasing yields and helping crops adapt to climate change. Many CRISPR-modified food crops are ready to go and a few are already on the market.”

“Summit organizers and participants are charged with making ‘game changing’ recommendations across food systems to help eliminate hunger on a global basis. It’s hard to see how they achieve that goal without embracing cutting-edge science at the heart of the food chain.”

The underlying rationale for the Summit is a painful recognition that the world is not on course to meet its 2030 Sustainable Development Goal (SDG) #2 to “end hunger, achieve food security and improve nutrition, and promote sustainable agriculture.” Summit organizers and participants are charged with making ‘game changing’ recommendations across food systems to help eliminate hunger on a global basis. It’s hard to see how they achieve that goal without embracing cutting-edge science at the heart of the food chain.

The Secretary General has selected Dr. Agnes Kalibata, President of the Alliance for a Green Revolution in Africa (AGRA), to lead the Food System Summit. Dr. Kalibata is an entomologist with a deep commitment to science and helping Africa grow itself out of poverty. The Secretary General’s selection of Kalibata also sends an important signal of what the Secretary General has in mind. 

Founded in 2006, AGRA is a farmer-centered, African-led, partnership-driven institution that is working to transform smallholder farming from a solitary subsistence struggle to a business that thrives. Agriculture accounts for a large percentage of the Gross Domestic Product in Africa and is the continent’s biggest employer

The United States will have an important role to play at the FSS. President Biden has reaffirmed his commitment to the United Nations and other international bodies, including the North America Treaty Organization (NATO) and the World Health Organization. Under the leadership of Secretary Tom Vilsack, with input from the Agency for International Development (AID), the State Department and the White House Office of Science and Technology Policy, we can expect a strong commitment to eliminating hunger while protecting the environment and gender equality, consistent with the other SDGs.

In 2018, the European Union Court of Justice, however, put a spotlight (some might say “target”) on CRISPR technology. The EU argued, broadly speaking, that CRISPR plant science applications be evaluated under the same regulatory framework as those GMO’s that rely on transgenic modification. The court’s decision was the focus of an article.

Also see: Gene editing: A path towards precision biotechnology in agriculture

In page 56: The Outlook for Agriculture and Rural Development in the Americas: A Perspective on Latin America and the Caribbean 2019-2020

The United States and many other advanced agriculture countries recognize that CRISPR is substantially different than transgenic modification and merits a different review framework. It remains to be seen whether such divergent scientific approaches emerge as a point of friction at the FSS culminating this September as a part of the UN General Assembly in New York.

Other global players will have important voices at the FSS, including: 

  • The UN FSS leadership including the UN’s World Food Program and the Food and Agriculture Organization.
  • The Tony Blair Institute (founded by the former UK Prime Minister) now has offices in over 20 countries, has made agriculture one of his major areas of focus, and is very respected at the UN. 
  • CGIAR (formerly the Consultative Group on International Agriculture Research) has been advising policy makers on agriculture for 50 years.
  • The Inter-American Institute for Cooperation in Agriculture (IICA).
  • The Rockefeller Foundation (RF), the original supporter or Dr. Norman Borlaug and the Green Revolution, is now headed by Dr. Raj Shah, formerly with USAID and the Gates Foundation. 
  • The Gates Foundation which launched AGRA along with the Rockefeller Foundation.
  • The Syngenta Foundation.
  • Volcani International Partnership in Israel, and many others, are all deeply involved in the effort to eliminate hunger and can be expected to participate.
  • The Seed Systems Group based in Kenya is led by Dr. Joe DeVries, formerly with AGRA and the RF.
  • Dr. Akin Adesina, President of the African Development Bank is the former Minister of Agriculture in Nigeria and VP of AGRA, and
  • Many others.

“The United States and many other advanced agriculture countries recognize that CRISPR is substantially different than transgenic modification and merits a different review framework.”

It is reasonable to expect the EU to try and further an agenda consistent with the EU’s Farm to Fork 2030 Goals. Their Goals call for the arbitrary, across the board, reduction of pesticides and fertilizer. Paradoxically, achieving these goals can be vastly facilitated using the newest CRISPR-based gene-editing techniques. 

In short, the FSS presents both risks and opportunities for American agriculture. It is important to stay informed and involved.
 

Marshall Matz specializes in global food security at OFW Law in Washington, D.C. He has devoted his career to representing clients that are increasing food production and improving human nutrition in the United States and around the world. In addition to his law practice, Marshall serves on the Board of Directors of the Food Research and Action Center (FRAC), World Food Program USA (which he co-founded), the Congressional Hunger Center and the Lower Brule Sioux Tribe Farm Corporation. 


Note: The opinions expressed in this article are the responsibility of the authors and do not necessarily reflect the opinion of IICA.

 

If you have questions or suggestions for improving the IICA Blog, please write to the editors: Joaquín Arias and Viviana Palmieri.

 

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